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Atherosclerosis

Coronary disease markers are unaffected by modest dosing of renin-angiotensin system inhibition

Published in Drug Week, October 20th, 2006

Coronary atherosclerotic disease biomarkers are unaffected by modest dosing of an angiotensin-converting enzyme inhibitor, antiotensin II type-1 receptor blocker, and the combination.

According to recent research from the United States, "Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers, used alone or in combination, have been shown to improve outcomes in certain populations, primarily when administered in high doses. For stable coronary atherosclerotic disease, however, the relative physiologic effect of these therapies is unclear."

"Furthermore," wrote J.P. Tsikouris and colleagues at University of Pittsburgh,...

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