Published in Drug Week, October 20th, 2006
Study 1: Type 1 diabetes models show neovascular improvement with reactive oxygen species (ROS) control.
"We hypothesized that diabetes-induced oxidative stress may affect postischemic neovascularization. The response to unilateral femoral artery ligation was studied in wild-type or gp91(phox)-deficient control or type 1 diabetic mice or in animals treated with the anti-oxidant N-acetyl-L-cysteine (NAC) or with in vivo electrotransfer of a plasmid encoding dominant-negative Rac1 (50 mcg) for 21 days," scientists writing in the American Journal of Pathology report.
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