Published in Drug Week, October 20th, 2006
"Several lines of evidence suggest that stem cells are major targets for carcinogens. A normal human breast epithelial cell type was previously shown to possess stem cell characteristics," researchers in Italy report.
According to the authors, "Further cell lines were derived following sequential transfection with SV40 large T-antigen (immortal, nontumorigenic M13SV1 cells), exposure to X-rays (weakly tumorigenic M13SV1R2 cells), and ectopic expression of c-erbB2/neu (highly tumorigenic M13SV1R2N1 cells).
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