Published in Drug Week, October 27th, 2006
Study 1: In a recently published article, scientists from France reported that early steps of human immunodeficiency virus, type 1 (HIV-1) replication inhibited by integration with viral integrase (IN).
"To replicate, HIV-1 needs to integrate a cDNA copy of its RNA genome into a chromosome of the host cell, a step controlled by the viral IN protein. Viral integration involves the participation of several cellular proteins.
"SNF5/Ini1, a subunit of the SWI/SNF chromatin remodeling complex, was the first cofactor identified to interact with IN....
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