Cancer Therapy
Data on cancer therapy described by researchers at University of South Alabama
Published in Drug Week, December 15th, 2006
Investigators publish new data in the report "Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha. Cantharidin, a natural vesicant, inhibits the activity of several PPP family phosphatases, displays antitumor activity, and induces apoptosis in many types of tumor cells. However, the molecular mechanisms underlying the antitumor activity of cantharidin are not clear," scientists in the United States report.
"Here, dose-response studies confirm a strong correlation between the suppression of phosphatase activity and cell death. Flow cytometry analysis...
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Source: Drug Week (2006-12-15)
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