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Pharmacology

Study findings from University of Zaragoza broaden understanding of pharmacology

Published in Drug Week, January 5th, 2007

Investigators publish new data in the report "Role of chloride transport proteins in the vasorelaxant action of nitroprusside in isolated rat aorta. Chloride ions play a key role in smooth muscle contraction, but little is known concerning their role in smooth muscle relaxation. Here we investigated the effect of chloride transport inhibitors on the vasorelaxant responses to nitroprusside in isolated and endothelium-denuded rat aorta, precontracted with phenylephrine 1 muM," scientists in Spain report.

"Incubation of aortic rings in NO(3)(-) media strongly potentiated the vasorelaxant responses to nitroprusside. Bumetanide, DIDS...

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