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Biotechnology
Research from Chosun University, Research Center for Proteineous Materials has provided new data on biotechnology
January 19th, 2007
Investigators publish new data in the report "Mechanism of antibacterial action of a synthetic peptide with an Ala-peptoid residue based on the scorpion-derived antimicrobial peptide IsCT." According to recent research from Korea, "A novel bacterial cell-selective antimicrobial peptide, IsCT-P (ILKKIWKPIKKLF-NH(2)), was designed based on the scorpion-derived alpha-helical antimicrobial peptide, IsCT. Here, we investigated the effect of substituting Pro(8) of IsCT-P with the Ala-peptoid residue (N-methylglycine) on the peptide's structure and mechanism of action." "Circular dichroism analysis revealed that the modified peptide, IsCT-a, has a much lower alpha-helicity...
Source: Drug Week (2007-01-19)
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