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Phenylketonuria

BioMarin announces positive results from phase III study of Phenoptin

Published in Drug Week, February 16th, 2007

BioMarin Pharmaceutical, Inc., (BMRN) announced positive results from the phase III diet study of Phenoptin (sapropterin dihydrochloride), in combination with diet, in 4-12 year old patients.

Phenoptin is an investigational oral small molecule, being developed in partnership with Merck Serono, for the treatment of patients with phenylketonuria (PKU), who have elevated phenylalanine (Phe) levels. The results show that all pre-specified efficacy and safety endpoints of the double-blind, placebo-controlled study were met. Phenoptin treatment caused a significant increase in phenylalanine tolerance as well as a reduction in blood phenylalanine levels. In addition, the data...

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