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Arthritis Therapy
Data from Research Center, Department of Biology provide new insights into arthritis therapy
March 2nd, 2007
Scientists discuss in "Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo" new findings in arthritis. "The chemokine receptor CCR1 is a potential target for the treatment of rheumatoid arthritis. To explore the impact of CCR1 blockade in experimental arthritis and the underlying mechanisms, we used J-113863, a non-peptide antagonist of the mouse receptor," scientists in Barcelona, Spain report. "EXPERIMENTAL APPROACH: Compound J-113863 was tested in collagen-induced arthritis (CIA) and three models of acute inflammation; Staphylococcus enterotoxin B (SEB)-induced interleukin-2 (IL-2), delayed-type hypersensitivity (DTH)...
Source: Drug Week (2007-03-02)
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