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Colon Cancer Therapy
Research from Dabur Research Foundation yields new findings on colon cancer therapy
March 2nd, 2007
Fresh data on colon cancer are presented in the report "Bombesin analogs containing alpha-amino-isobutyric acid with potent anticancer activity. Six octapeptide bombesin (BN) analogs were synthesized by substituting alpha-aminoisobutyric acid (Aib), in place of Ala9 or Gly11, or both, in the [D-Phe6, desMet14]-BN (6-14) sequence: D-Phe6-Gln7-Trp8-Ala9-Val10-Gly11-His12-Leu13-NH2 (P0). Additionally, Leu13 was replaced with isoleucine in two analogs and one of the analogs was butanoylated at the N-terminus," scientists writing in the Journal of Peptide Science report. "The antiproliferative activity of the analogs was tested in vitro on human pancreatic (MiaPaCa-2)...
Source: Drug Week (2007-03-02)
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