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Depression
Reports outline depression research from Sutcu Imam University, Department of Pharmacology
March 2nd, 2007
Investigators publish new data in the report "Prevention of pro-depressant effect of L-arginine in the forced swim test by NG-nitro-L-arginine and [1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one]." According to a study from Kahramanmaras, Turkey, "Previous studies have shown that l-arginine, the precursor of nitric oxide, has a dual effect (antidepressant and pro-depressant) in the forced swim test. The aim of the present study was to investigate whether nitric oxide-cGMP pathway was involved in this dual effect." "Porsolt swim test was conducted to resemble the symptomatology of major depressive disorder. An open field locomotor activity test was also used. L-arginine...
Source: Drug Week (2007-03-02)
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