Drug Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Anti-Infectives
Recent findings in anti-infectives described by researchers from Furman University, Department of Chemistry
March 2nd, 2007
Data detailed in "Hydration changes accompanying the binding of minor groove ligands with DNA" have been presented. "4',6-diamidino-2-phenylindole (DAPI), netropsin, and pentamidine are minor groove binders that have terminal -C(NH2)2+ groups. The hydration changes that accompany their binding to the minor groove of the (AATT)2 sequence have been studied using the osmotic stress technique with fluorescence spectroscopy," scientists writing in the Biophysical Journal report. "The affinity of DAPI for the binding site decreases with the increasing osmolality of the solution, resulting in acquisition of 35±1 waters upon binding. A competition fluorescence...
Source: Drug Week (2007-03-02)
|
