Toxicology
Research from Maastricht University, Nutrition and Toxicology Research Institute broadens understanding of toxicology
Published in Drug Week, March 23rd, 2007
New research, "Local effect of adenosine 5'-triphosphate on indomethacin-induced permeability changes in the human small intestine," is the subject of a report. "Nonsteroidal anti-inflammatory drug (NSAID) use is associated with an elevated risk of gastrointestinal damage. As adenosine 5'-triphosphate (ATP) may play a protective role in the small intestine, our objective was to determine the local effect of ATP on small intestinal permeability changes induced by short-term challenge of the NSAID indomethacin in healthy humans," scientists in Maastricht, Netherlands report.
"Mucosal permeability of the small intestine was assessed by the lactulose/rhamnose permeability...
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Source: Drug Week (2007-03-23)
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