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Immunotherapy

Research reports on immunotherapy from University of Chicago, Department of Surgery provide new insights

Published in Drug Week, April 27th, 2007

New research, "Recognition of carcinoembryonic antigen peptide and heteroclitic peptide by peripheral blood T lymphocytes," is the subject of a report. According to recent research from the United States, "The carcinoembryonic antigen (CEA)-derived peptide CAP1 and heteroclitic peptide CAP1-6D are stimulators of HLA-A*A0201 restricted CEA-specific T cells in vivo and in vitro. The goal of this study was to evaluate differences in T cell responses to peptide and modified peptide antigens from CEA."

"The heterogeneity of responses among individuals is potentially important for the design of future CEA-directed immunotherapy trials. Peripheral blood mononuclear cells from...

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