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Physiology

Research from Duke University reveals new findings on physiology

Published in Drug Week, May 25th, 2007

Data detailed in "Functional characterization of two S-nitroso-L-cysteine transporters, which mediate movement of NO equivalents into vascular cells" have been presented. According to recent research from the United States, "System L amino acid transporters have been shown to be responsible for cellular uptake of S-nitroso-L-cysteine (l-CSNO). In this study, we examined the characteristics of L-CSNO uptake in Xenopus laevis oocytes expressing system L transporters and found that uptake increased only when both 4F2 heavy chain (4F2HC) and either L-type amino acid transporter 1 (LAT1) or LAT2 light chain were coexpressed."

"The K(m) for transport was 57 ±8 microM...

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