Osteosarcoma Therapy

New findings from Rizzoli Orthopaedic Institute describe advances in osteosarcoma therapy

Published in Drug Week, June 22nd, 2007

Current study results from the report, "Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells," have been published. According to a study from Bologna, Italy, "Since osteosarcoma is a drug-resistant disease, the aim of the present study was to explore the possible interest of therapeutic approaches including nitrogen-containing biphosphonate zoledronic acid using osteosarcoma cell lines with different genetic backgrounds. Parental p53+/pRb+ U2-OS, p53-mutant U2-OS (U2-OS/175) and p53-/pRb-SAOS were sensitive to zoledronic acid with no significant differences in IC₅₀ values."

"Analysis of cell cycle distribution revealed a...

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Source: Drug Week (2007-06-22)

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