Hepatology

Reports outline hepatology research from INSERM

Published in Drug Week, June 22nd, 2007

Researchers detail in "High hepatic glutathione stores alleviate Fas-induced apoptosis in mice," new data in hepatology. According to a study from Paris, France, "The agonistic Jo2 anti-Fas antibody reproduces human fulminant hepatitis in mice. We tested the hypothesis that enhancing hepatic glutathione (GSH) stores may prevent Jo2-induced apoptosis."

"We fed mice with a normal diet or a sulfur amino acid-enriched (SAA(+)) diet increasing hepatic GSH by 63%, and challenged these mice with Jo2. The SAA(+) diet markedly attenuated the Jo2-mediated decrease in hepatic GSH and the increase in the oxidized glutathione (GSSG)/GSH ratio in cytosol and mitochondria. The SAA(+)...

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Source: Drug Week (2007-06-22)

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