Biological Chemistry
Researchers from University of British Columbia, Center for Blood Research describe findings in biological chemistry
Published in Drug Week, July 6th, 2007
A new study, "Selective inhibition of the collagenase activity of cathepsin K," is now available. "Cathepsin K, the main bone degrading protease, and chondroitin 4-sulfate (C4-S) form a complex with enhanced collagenase activity. In this report, we demonstrate the specific inhibition of the collagenase activity of cathepsin K by negatively charged polymers without affecting the overall proteolytic activity of the protease," scientists writing in the Journal of Biological Chemistry report.
"Three different mechanisms to interfere with cathepsin-catalyzed collagen degradation are discussed: 1) inhibition of the formation of the cathepsin K/C4-S complex, 2)...
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Source: Drug Week (2007-07-06)
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