Experimental Therapeutics
Research conducted at University of North Carolina has provided new information about experimental therapeutics
Published in Drug Week, July 6th, 2007
Scientists discuss in "Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity" new findings in experimental therapeutics. According to a study from the United States, "Bile acid accumulation in hepatocytes due to inhibition of the canalicular bile salt export pump (BSEP/ABCB11) has been proposed as a mechanism for bosentan-induced hepatotoxicity. The observation that bosentan does not induce hepatotoxicity in rats, although bosentan has been reported to inhibit rat Bsep and cause elevated serum bile acids, challenges this mechanism."
"The lack of...
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Source: Drug Week (2007-07-06)
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