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Boston University

Circadian system suffers and protects from prenatal cocaine exposure

Published in Drug Week, July 27th, 2007

Researchers from Boston University School of Medicine (BUSM) have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission.

The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11th issue of the journal PLoS ONE.

Tens of thousands of babies that have been exposed to cocaine in utero are born in the United States each year.

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