Pulmonary Fibrosis Therapy
Studies from GlaxoSmithKline, Pharmacology Department describe new findings in pulmonary fibrosis therapy
Published in Drug Week, August 10th, 2007
Research findings, "Inhibition of activin receptor-like kinase 5 attenuates Bleomycin-induced pulmonary fibrosis," are discussed in a new report. "Activin receptor-like kinase 5 (ALK5) is a type I receptor of transforming growth factor (TGF)-beta. ALK5 inhibition has been reported to attenuate the tissue fibrosis including pulmonary fibrosis, renal fibrosis and liver fibrosis," scientists in Ibaraki, Japan report.
"To elucidate the inhibitory mechanism of ALK5 inhibitor on pulmonary fibrosis in vivo, we performed the histopathological assessment, gene expression analysis of extracellular matrix (ECM) genes and immunohistochemistry including receptor-activated Smads...
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Source: Drug Week (2007-08-10)
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