Biochemistry
Research from University of Helsinki, Division of Pharmaceutical Chemistry in the area of biochemistry published
Published in Drug Week, August 17th, 2007
Current study results from the report, "Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation," have been published. "SULT1A3 is an enzyme that catalyzes the sulfonation of many endogenous and exogenous phenols and catechols. The most important endogenous substrate is dopamine (DA), which is often used as a probe substrate for SULT1A3," researchers in Helsinki, Finland report.
"We developed a new method for analyzing the SULT1A3 reaction products by high-performance liquid chromatography (HPLC) with electrochemical detection. The sulfonate donor...
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Source: Drug Week (2007-08-17)
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