Biological Chemistry

Data on biological chemistry described by J.R.M. Ojala et al

Published in Drug Week, August 24th, 2007

According to a study from Stockholm, Sweden, "MARCO is a trimeric class A scavenger receptor of macrophages and dendritic cells that recognizes polyanionic particles and pathogens. The distal, scavenger receptor cysteine-rich (SRCR) domain of the extracellular part of this receptor has been implicated in ligand binding."

"To provide a structural basis for understanding the ligand-binding mechanisms of MARCO, we have determined the crystal structure of the mouse MARCO SRCR domain. The recombinant SRCR domain purified as monomeric and dimeric forms, and their structures were determined at 1.78 and 1.77A resolution, respectively. The monomer has a compact globular fold...

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Source: Drug Week (2007-08-24)

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