Alzheimer Disease
Researchers link metal ions to neurodegenerative disease
Published in Drug Week, August 24th, 2007
A multi-institutional team of researchers led by Emory University has defined for the first time how metal ions bind to amyloid fibrils in the brain in a way that appears toxic to neurons. Amyloid fibrils are linked to the development of neurodegenerative diseases such as Alzheimer's, Parkinson's and Creutzfeldt-Jakob. Although metal ions, most notably copper, can bind to amyloid in several specific ways, the researchers found that only one way appears toxic.
The findings will appear in the Proceedings of the National Academy of Sciences, Early Edition online during the week of Aug. 6-10 and in the Aug. 14 print edition.
Copper ions, atoms that have...
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Source: Drug Week (2007-08-24)
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