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Microbiology

Research from University of Bologna, Center for Biotechnology in microbiology provides new insights

Published in Drug Week, August 24th, 2007

Researchers detail in "Genetic and proteomic characterization of rifaximin resistance in Bifidobacterium infantis BI07," new data in microbiology. According to recent research from Bologna, Italy, "Rifaximin resistance in the probiotic strain Bifidobacterium infantis BI07 was studied to assess the use of an antibiotic-probiotic combination for clinical management of intestinal disorders. A rifaximin-resistant mutant was selected and a 129 bp core region of the rpoB gene was sequenced and compared with the respective sequence of the sensitive clone."

"A miss-sense mutation of codon 513, producing the substitution of Gln with Arg in the protein sequence, was found. The...

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