Hepatitis C Virus
R7128 Demonstrates Safety and Potent Antiviral Activity in HCV-Infected Patients
Published in Drug Week, September 28th, 2007
Pharmasset, Inc. (NASDAQ:VRUS) reports preliminary safety and potent antiviral activity with R7128 following 14 days of monotherapy in 40 patients chronically infected with hepatitis C virus (HCV) who have failed prior interferon therapy. R7128 is a prodrug of PSI-6130, an oral cytidine nucleoside analog polymerase inhibitor of HCV that is being developed through Pharmasset's collaboration with Roche. The Phase 1 multiple ascending dose study of R7128 was designed to evaluate safety, tolerability, pharmacokinetics and preliminary antiviral activity.
R7128 demonstrated potent, dose-dependent antiviral activity across the four patient cohorts (n=3D10; 8 active, 2 placebo)...
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Source: Drug Week (2007-09-28)
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