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Addiction Medicine

New genetic research into nicotine addiction shows promise for personalized treatment

Published in Drug Week, October 5th, 2007

Whether a smoking-cessation drug will enable you to quit smoking may depend on your genes, according to new genotyping research from the Centre for Addiction and Mental Health (CAMH). The study, published in the September issue of the journal Biological Psychiatry, found that the enzyme known to metabolize both the smoking cessation drug bupropion and nicotine is highly genetically variable in all ethnicities and influences smoking cessation. This finding is a step toward being able to tailor smoking cessation treatment to individuals based on their unique genetic make-up.

“This first study identifies a very common genetic variant (present in anywhere from 25 to 50...

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