Pharmacology
Data on pharmacology detailed by researchers at Weill Cornell Medical College, Department of Anesthesiology
Published in Drug Week, October 5th, 2007
Current study results from the report, "Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel," have been published. According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "Volatile anesthetics inhibit mammalian voltage-gated Na(+) channels, an action that contributes to their presynaptic inhibition of neurotransmitter release. We measured the effects of isoflurane, a prototypical halogenated ether volatile anesthetic, on the prokaryotic voltage-gated Na(+) channel from Bacillus halodurans (NaChBac)."
"Using whole-cell patch-clamp recording, human embryonic kidney 293 cells transfected with NaChBac...
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Source: Drug Week (2007-10-05)
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