Published in Drug Week, October 19th, 2007
"In this study, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models, we investigated whether MPTP induces apoptosis of dopaminergic neurons through a GSK-3 beta-dependent pathway. MPTP caused a rapid activation of GSK-3 beta, evidenced by the decrease in level of phospho-Ser9 of GSK-3 beta and the...
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