Parkinson Disease

Studies from W.Y. Wang and co-researchers yield new data on parkinson disease

Published in Drug Week, October 19th, 2007

"Glycogen synthase kinase-3 beta (GSK-3 beta) is closely involved in neuronal apoptosis and pathogenesis of many neurodegenerative diseases, such as Alzheimer's disease. However, whether GSK-3 beta mediates apoptosis of dopaminergic neurons in Parkinson's disease remains elusive," researchers in Guangzhou, People's Republic of China report.

"In this study, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models, we investigated whether MPTP induces apoptosis of dopaminergic neurons through a GSK-3 beta-dependent pathway. MPTP caused a rapid activation of GSK-3 beta, evidenced by the decrease in level of phospho-Ser9 of GSK-3 beta and the...

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Source: Drug Week (2007-10-19)

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