Addiction Medicine

Tolerance to inhalants may be caused by changes in gene expression

Published in Drug Week, November 2nd, 2007

Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered.

The team, led by graduate student Yan Wang, used the fruit fly Drosophila melanogaster as a model system to determine how the nervous system becomes tolerant to sedation with organic solvent inhalants.

The team's work appears in the October 16 issue of Public Library of Science-Biology.

"Drug tolerance causes the user to consume more of the drug, speeding them down the path of addiction," said Nigel Atkinson, an associate...

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Source: Drug Week (2007-11-02)

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