Apoptosis

Reports outline apoptosis study findings from Johns Hopkins University

Published in Drug Week, November 2nd, 2007

"' To elucidate the role of activated microglia and nitric oxide (NO) in photoreceptor apoptosis in rds mice, and to investigate the effect of minocycline treatment on rds mice. Photoreceptor apoptosis in rds mice was detected by terminal dUTP transferase nick end labeling (TUNEL)," investigators in the United States report.

"Retinal microglial cells were identified by CD11b antibody. The mRNA expression of inducible nitric oxide synthase (iNOS) and chemokines were examined by reverse transcription polymerase chain reaction (RT-PCR) assay. The protein expression of iNOS was examined by immunohistochemistry and Western blotting analysis. The rds mice were treated...

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Source: Drug Week (2007-11-02)

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