Fresh data on tuberculosis are presented in the report 'Interleukin-12p40 overexpression promotes interleukin-12p70 and interleukin-23 formation but does not affect bacille Calmette-Guérin and Mycobacterium tuberculosis clearance.' According to recent research published in the journal Immunology, "Interleukin (IL)-12p40, a subunit of IL-12p70 and IL-23, has previously been shown to inhibit IL-12p70 activity and interferon-gamma (IFN-gamma) production. However, recent evidence has suggested that the role of IL-12p40 is more complex."
"To study the contribution of IL-12p40 to immune responses against mycobacterial infections, we have used transgenic (tg) mice...
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