Life Sciences
Studies from M. Yoshida and co-researchers update current data on life sciences
Published in Drug Week, February 29th, 2008
Scientists discuss in 'Effect of concomitant treatment with a CYP3A4 inhibitor and a calcium channel blocker' new findings in life sciences. According to recent research from Japan, "Grapefruit juice has been found to interact with calcium channel blockers (CCB). This interaction is due to certain nutrients found in grapefruit juice that block the activity of cytochrome P-450 (CYP) 3A4 in the small intestine and liver."
"Inhibition of CYP3A4 markedly increases bioavailability and increases the risk of an adverse drug reaction (ADR). Many drugs are known to have CYP3A4-blocking activity. This study was performed to investigate whether the concomitant use of a CYP3A4...
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Source: Drug Week (2008-02-29)
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