Blood Pressure

Data on blood pressure discussed by K.S. Vimaleswaran and colleagues

Published in Drug Week, April 11th, 2008

"The endothelial nitric-oxide synthase (NOS3) gene encodes the enzyme (eNOS) that synthesizes the molecule nitric oxide, which facilitates endothelium-dependent vasoclilation in response to physical activity. Thus, energy expenditure may modify the association between the genetic variation at NOS3 and blood pressure," researchers in Cambridge, the United Kingdom report.

"To test this hypothesis, we genotyped 11 NOS3 polymorph isms, capturing all common variations, in 726 men and women from the Medical Research Council (MRC) Ely Study (age (mean s.d.): 55 +/- 10 years, body mass index: 26.4 +/- 4.1 kg/m(2)). Habitual/non-resting energy expenditure (NREE) was assessed via...

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Source: Drug Week (2008-04-11)

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