Breast Cancer

Researchers detail chemotherapy's damage to the brain

Published in Drug Week, May 9th, 2008

A commonly used chemotherapy drug causes healthy brain cells to die off long after treatment has ended and may be one of the underlying biological causes of the cognitive side effects – or "chemo brain" – that many cancer patients experience. That is the conclusion of a study published in the Journal of Biology.

A team of researchers at the University of Rochester Medical Center (URMC) and Harvard Medical School have linked the widely used chemotherapy drug 5-fluorouracil (5-FU) to a progressing collapse of populations of stem cells and their progeny in the central nervous system.

"This study is the first model of a delayed degeneration syndrome that...

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Source: Drug Week (2008-05-09)

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