Pharmacokinetics

New pharmacokinetics research from Hokkaido University, Medical Department outlined

Published in Drug Week, May 9th, 2008

"BAL is an established technique for measuring antibiotic concentrations in the epithelial lining fluid (ELF) of the bronchiolar-alveolar regions. However, the results may not reflect concentrations in bronchial regions," scientists in Sapporo, Japan report.

"Bronchoscopic microsampling (BMS) is a technique for repeated sampling of bronchial ELF. The objective of the present study was to determine the time versus concentration profile of clarithromycin and its active metabolite, 14-hydroxy-clarithromycin, in bronchial ELF, as determined by BMS. BMS was performed at 1, 2, 3, 5 and 10 h after a single oral administration of 200 mg clarithromycin in five healthy...

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Source: Drug Week (2008-05-09)

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