Pharmacology and Experimental Therapeutics

Research from State University of New York in pharmacology and experimental therapeutics provides new insights

Published in Drug Week, August 15th, 2008

According to recent research published in the Journal of Pharmacology and Experimental Therapeutics, "Identification of adaptations to chronic morphine that are causally associated with opioid tolerance formation has long been intensely pursued by the opioid research community. There is an impressive array of components of signaling pathways that are influenced by chronic opioid administration."

"This underscores the importance to tolerance mechanisms of the complex interplay of cellular adaptations that are downstream from the opioid receptor. A major impetus for this research remains the need to develop opioid agonists that are potent and efficacious activators...

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Source: Drug Week (2008-08-15)

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