Thrombocytopenia

Studies in the area of thrombocytopenia reported from K. Pavenski and co-researchers

Published in Drug Week, October 31st, 2008

According to recent research published in the journal Transfusion, "Passive transfer of platelet (PLT) antibody by blood transfusion can lead to severe thrombocytopenia, bleeding, and an acute transfusion reaction. A 49-year-old male on warfarin developed thrombocytopenic bleeding within 2 hours of transfusion with a single unit of fresh-frozen plasma (FFP)."

"The patient's PLT count on admission was 122 x 109 per L. Two hours after transfusion, PLT count has decreased to 5 x 109 per L. The patient's PLT antibody screen by solid-phase enzyme-linked immunosorbent assay was negative and his genotype was HPA-1a/1b. The donor's genotype was HPA-1b/1b and antibody...

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Source: Drug Week (2008-10-31)

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