Cancer

Recent findings from University of New South Wales highlight research in cancer

Published in Drug Week, January 2nd, 2009

According to a study from Sydney, Australia, "N-(2-Hydroxypropyl)methacrylamide (HPMA) containing polymers that are widely used as anticancer drug carriers. We have synthesized new amphiphilic block copolymers of HPMA with a functional monomer 2-(2-pyridyldisulfide)ethylmethacrylate (PDSM) via reversible addition-fragmentation chain transfer (RAFT) polymerization."

"In a one-pot reaction, the versatility of PDS groups on poly(PDSM)-b-poly(HPMA) was used to conjugate an anticancer drug, doxorubicin (DOX), and also simultaneously crosslink the micellar assemblies via acid-cleavable hydrazone bonds and reducible disulfide bonds. DOX-conjugated crosslinked micelles with an...

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Source: Drug Week (2009-01-02)

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