American Journal of Pathology

New technique for cancer screening

Published in Drug Week, March 13th, 2009

Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis," appears in the March 2009 issue of The Journal of Molecular Diagnostics.

DNA in tumors is often altered compared with DNA in normal tissues. One common DNA alteration in cancerous tissue is hypermethylation, which results in loss of gene expression. The difference in methylation between normal and cancerous tissues can be used as a biomarker for early cancer...

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Source: Drug Week (2009-03-13)

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