Life Sciences
New life sciences research from Soochow University outlined
Published in Drug Week, April 24th, 2009
Investigators publish new data in the report 'High efficiency adenovirus-mediated expression of truncated N-terminal huntingtin fragment (htt552) in primary rat astrocytes.' "Huntington's disease (HD) is caused by an expansion of polyglutamine tract in N-terminus of huntingtin (htt). The mutation of htt leads to dysfunction and premature death of striatal and cortical neurons," scientists in Suzhou, People's Republic of China report.
"However, the effects of htt mutation on glia remain largely unknown. This study aimed to establish a glia HD model using an adenoviral vector to express wild-type and mutant N-terminal huntingtin fragment 1-552 amino acids (htt552) in rat...
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Source: Drug Week (2009-04-24)
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