Enzyme Research

Research reports on enzyme research from Yokohama City University provide new insights

Published in Drug Week, June 5th, 2009

According to recent research from Yokohama, Japan, "DNA topoisomerase I (Top1) is a ubiquitous nuclear enzyme that plays essential roles in various cellular processes, such as transcription or replication. Agents that target Top1, involving camptothecin and its derivatives, are among the most effective anticancer drugs used in the clinic."

"Previous work has suggested that the level of Top1 expression correlates with the cytotoxicity of camptothecin, but no direct evidence has been provided thus far in the context of human cells with a strictly isogenic genetic background. In this study, we perform heterozygous disruption of the Top1 gene (TOP1) by gene targeting in a...

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Source: Drug Week (2009-06-05)

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