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Physiology

Findings from R. Kiefmann and co-authors broaden understanding of physiology

Published in Drug Week, August 7th, 2009

"Kiefmann R, Islam MN, Lindert J, Parthasarathi K, Bhattacharya J. Paracrine purinergic signaling determines lung endothelial nitric oxide production. Am J Physiol Lung Cell Mol Physiol 296: L901-L910, 2009," investigators in the United States report.

"First published March 20, 2009; doi: 10.1152/ajplung.90549.2008.-Although the vascular bed is a major source of nitric oxide (NO) production, factors regulating the production remain unclear. We considered the role played by paracrine signaling. Determinations by fluorescence microscopy in isolated, blood-perfused rat and mouse lungs revealed that a brief lung expansion enhanced cytosolic Ca2+ (Ca(2+)cyt) oscillations in...

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