Gene Therapy
Reports on gene therapy findings from Showa University provide new insights
Published in Drug Week, September 18th, 2009
According to recent research from Tokyo, Japan, "Mitochondrial dysfunction, in particular, interference in the respiratory chain, is often responsible for the toxicogenic effects of xenobiotics. In this study, changes in gene expression resulting from pharmacological inhibition of the respiratory chain were studied by DNA microarray analysis using cells treated with rotenone or antimycin A, which inhibit complexes I and III of the electron transport system, respectively."
"Forty-eight genes were either up- or down-regulated more than 3-fold. These included stress- and/or metabolic-related effector genes and several transcriptional regulators represented by CHOP-10....
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Source: Drug Week (2009-09-18)
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