Hemophilia A
Research on hemophilia a discussed by C. Kessel and co-researchers
Published in Drug Week, October 16th, 2009
"About 30% of patients with severe hemophilia A develop neutralizing antibodies (inhibitors) to coagulation factor VIII (FVIII) upon treatment with exogenous factor preparations. Two peptides, C6 (NPVENMMDRDSQ) and H10 (QSPWQTWFTRAL), that mimic putative inhibitor epitopes (mimotopes), were previously selected by phage display screening of plasma samples from patients with inhibitors," investigators in Stockholm, Sweden report.
"Synthetic peptide mimotopes inhibited IgG binding to will (IC50: 30-50 mc M). This effect was increased by an equimolar combination of both mimotopes. Mimotopes were fused to the C-terminal multimerization domain of the C4bp alpha-chain and...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Drug Week
Source: Drug Week (2009-10-16)
More Articles from Drug Week
- American Association for Cancer Research
Lack of social interaction affects health outcomes of breast cancer - American Friends of Tel Aviv University
Scary music is scarier with your eyes shut - American Gastroenterological Association
Antidepressant and placebo are equally effective in child pain relief - BioMed Central
Personality traits influencing weight loss - Boston University Medical Center
Researchers believe hormone therapy should not be stopped prior to mammograms - Elsevier Health Sciences
Paradoxically, food insecurity may be underlying contributor to overweight - More from this issue of Drug Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
