Piperazine Therapy
Findings in piperazine therapy reported from B.M. Costa and co-researchers
Published in Drug Week, December 18th, 2009
"N-Methyl-D-aspartate (NMDA) receptor antagonists that are highly selective for specific NMDA receptor 2 (NR2) subunits have several potential therapeutic applications; however, to date, only NR2B-selective antagonists have been described. Whereas most glutamate binding site antagonists display a common pattern of NR2 selectivity, NR2A > NR2B > NR2C > NR2D (high to low affinity), (2S*, 3R*)-1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid (PPDA) has a low selectivity for NR2C- and NR2D-containing NMDA receptors," scientists writing in the Journal of Pharmacology and Experimental Therapeutics report.
"A series of PPDA derivatives were...
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Source: Drug Week (2009-12-18)
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