Thrombosis

Findings from St. Thomas' Hospital provide new insights into thrombosis

Published in Drug Week, December 18th, 2009

According to a study from London, the United Kingdom, "Our previous studies showed that the direct injection of an adenovirus construct expressing urokinase-type plasminogen activator (uPA) into experimental venous thrombi significantly reduces thrombus weight. The systemic use of adenovirus vectors is limited by inherent hepatic tropism and inflammatory response."

"As macrophages are recruited into venous thrombi, it is reasonable to speculate that these cells could be used to target the adenovirus uPA (ad-uPA) gene construct to the thrombus. The aims of this study were to determine whether macrophages transduced with ad-uPA have increased fibrinolytic activity and...

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Source: Drug Week (2009-12-18)

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