Lung Cancer
Scientists at Kanazawa University publish research in lung cancer
Published in Drug Week, December 18th, 2009
According to recent research published in the journal Clinical Cancer Research, "Lung cancers with epidermal growth factor receptor (EGFR)-activating mutations show good clinical response to gefitinib and erlotinib, selective tyrosine kinase inhibitors (TKI) to EGFR, but these tumors invariably develop drug resistance. Host stromal cells have been found to have a considerable effect on the behavior of cancer cells."
"Little is known, however, about the role of host cells on the sensitivity of cancer cells to receptor TKIs. We have therefore assessed the effect of crosstalk between stromal cells and lung cancer cells harboring EGFR mutations on susceptibility to...
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Source: Drug Week (2009-12-18)
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