Influenza

New influenza study findings have been reported by researchers at Northwestern University

Published in Drug Week, January 1st, 2010

According to a study from the United States, "Influenza A virus M2 (A/M2) and the influenza B virus BM2 are both small integral membrane proteins that form proton-selective ion channels. Influenza A virus A/M2 channel is the target of the antiviral drug amantadine (and its methyl derivative rimantadine), whereas BM2 channel activity is not affected by the drug."

"The atomic structure of the pore-transmembrane ™ domain peptide has been determined by x-ray crystallography [Stouffer et al. (2008) Nature 451: 596-599] and of a larger M2 peptide by NMR methods [Schnell and Chou (2008) Nature 451: 591-595]. The crystallographic data show electron density (at 3.5...

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Source: Drug Week (2010-01-01)

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