Helicobacter pylori

Data on helicobacter pylori detailed by S.H. Xuan and co-authors

Published in Drug Week, January 1st, 2010

"Macrolide drugs, such as clarithromycin (CAM), are a key component of many combination therapies used to eradicate Helicobacter pylori. However, resistance to CAM is increasing in H. pylori and is becoming a serious problem in H. pylori eradication therapy," scientists writing in the Journal of Medical Microbiology report.

"CAM resistance in H. pylori is mostly due to point mutations (A2142G/C, A2143G) in the peptidyltransferase-encoding region of the 23S rRNA gene. In this study an enzymic colorimetry-based DNA chip was developed to analyse sing le-nucleotide polymorphisms of the 23S rRNA gene to determine the prevalence of mutations in CAM-related resistance...

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Source: Drug Week (2010-01-01)

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